In the research fields of clinical analysis and bioanalytical sciences, there has been an ever increasing demand for efficient analytical tools. Therefore, a scientific field, linking bioanalytical techniques with microelectronics technology has been emerged and expanded. Especially, BIOSENSOR technology including immuno- or affinity-sensing, registering biospecific interactions such as antigen-antibody, ligand-receptor and protein-protein recognition reactions, is under great demand in terms of assay automation and multiplexing. Current research trends in biosensors or biochips area mainly include two directions. First one is the design and fabrication of biorecognition interfaces having desired characteristics such as surface functionality, immobilization density, biocompatibility, inertness to nonspecific binding. Second is the introduction of new signal generation techniques, particularly emphasizing multiplexed analysis with array-type sensors and automation. 

We have been working on the new technologies for the biospecific recognition layers and signaling strategies using fluorescent microspheres, retroreflective Janus particles, as well as enzyme-mediated bioelectrocatalysis. We are also aiming to integrate biosensing technologies with microfabrication processes in the format of lab chip, microfluidics, and paper-based microfluidics.